Leading Research about HBOT

Not all research is free (sorry, not our doing). But if you copy and paste the titles or the "doi:" you can see at least the abstracts. 
This list is ever growing and is largely made possible by the great Dr. Jason Sonners of HBOT USA located in Florham Park, NJ. He is a great resource for all things HBOT and is paramount in the education of up and coming clinicians. He has been an indispensable resource for us here at Integrated Hyperbarics and we cannot thank him enough.

** For information on HBOT with Post-Covid (long haul) see the More about HBOT page **

MECHANISM

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074

PAIN/INFLAMMATION

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Dulai PS, Gleeson MW, Taylor D, et al. (2014), Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharmacol Ther, 39: 1266-1275. doi:10.1111/apt.12753

Hui J, Zhang ZJ, Zhang X, et al. Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord, J. Pain, 14 (7) (2013), pp. 747-758

Li F, Fang L, Huang S, et al. Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production. Anesth. Analg., 113 (3) (2011), pp. 626-633

Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460

He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Treat. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632

Wu HH, Huang CC, Chang CP, et al. Heat shock protein 70 (HSP70) reduces hepatic inflammatory and oxidative damage in a rat model of liver ischemia/reperfusion injury with hyperbaric oxygen preconditioning. Med Sci Monit. 2018;24:8096–8104. Published 2018 Nov 12. doi:10.12659/MSM.911641

Thompson CD, Uhelski ML, Wilson JR, et al. Hyperbaric oxygen treatment decreases pain in two nerve injury models. Neurosci. Res., 66 (3) (2010), pp. 279-283

Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x

Zhao BS, Meng LX, Ding YY, et al. Hyperbaric oxygen treatment produces an antinociceptive response phase and inhibits astrocyte activation and inflammatory response in a rat model of neuropathic pain. J. Mol. Neurosci., 53 (2) (2014), pp. 251-261

Novak S, Drenjancevic I, Vukovic R, et al. Anti-inflammatory effects of hyperbaric oxygenation during DSS-induced colitis in BALB/c mice include changes in gene expression of HIF-1α, proinflammatory cytokines, and antioxidative enzymes. Mediators Inflamm. 2016;2016:7141430. doi:10.1155/2016/7141430

Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000

Di Sabato F, Rocco M, Martelletti P, et al. Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways. Undersea Hyperb. Med., 24 (2) (1997), pp. 117-122

Bennett MH, French C, Schnabel A, et al. Normobaric and hyperbaric oxygen therapy for migraine and cluster headache. Cochrane Database Syst. Rev. (3)(2008). 

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940
MZ Kiralp, Ş Yildiz, D Vural, I Keskin, H Ay, H Dursun Effectiveness of Hyperbaric Oxygen Therapy in the Treatment of Complex Regional Pain Syndrome 

J of Int Medical Research First Published May 1, 2004 https://doi.org/10.1177/147323000403200304

WOUND HEALING (P.S. everything is a wound)

Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser. 2017;17(5):1–142. Published 2017 May 12.

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000

Perren S, Gatt A, Papanas N, et al. Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial. Open Cardiovasc Med J. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080

Eskes AM, Ubbink DT, Lubbers MJ, et al. Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review. World J Surg. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4

Adjunctive Hyperbaric Oxygen Therapy for Healing of Chronic Diabetic Foot Ulcers: A Randomized Controlled Trial - PubMed (nih.gov)

TBI/CONCUSSION

Paul G Harch  Systematic Review and Dosage Analysis: Hyperbaric Oxygen Therapy Efficacy in Mild Traumatic Brain Injury Persistent Postconcussion Syndrome  Front Neurol 2022 Mar 17;13:815056. doi: 10.3389/fneur.2022.815056. eCollection 2022.

Paul G Harch, Susan R Andrews, Cara J Rowe, Johannes R Lischka, Mark H Townsend, Qingzhao Yu, Donald E Mercante  Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial  Med Gas Res 2020 Jan-Mar;10(1):8-20. doi: 10.4103/2045-9912.279978.

B Robert Mozayeni, William Duncan, Eddie Zant, Tommy L Love, Robert L Beckman, Kenneth P Stoller  The National Brain Injury Rescue and Rehabilitation Study - a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms  Med Gas Res. 2019 Jan-Mar;9(1):1-12. doi: 10.4103/2045-9912.254636.

Amir Hadanny, Merav Catalogna, Slava Yaniv, Orit Stolar, Lynn Rothstein, Adi Shabi, Gil Suzin, Efrat Sasson, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Ruth Tock Harpaz, Moran Adler, Ron-El Goldman, Yonatan Zemel, Yair Bechor & Shai Efrati   Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial  Scientific Reports volume 12, Article number: 15233 (2022) 

(THIS STUDY WAS THE FIRST EVER TO TRY A CONTROLLED STUDY OF HBOT ON CHILDREN. IT WAS MET WITH PARENT REFUSAL TO PARTICIPATE BECAUSE THERE WAS A 50% CHANCE THEIR CHILD WOULD NOT RECEIVE THE REAL TREATMENT. THIS WILL BE A LIMITING FACTOR IN PRODUCING MORE RESEARCH FOR HBOT STUDIES ON CHILDREN. BUT WE COMPLETELY UNDERSTAND WHY THEY DID IT.)

Xavier A Figueroa, James K Wright    Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials - PubMed (nih.gov)   Neurology 2016 Sep 27;87(13):1400-6.

James K Wright, Eddie Zant, Kevin Groom, Robert E Schlegel, Kirby Gilliland   Case report: Treatment of mild traumatic brain injury with hyperbaric oxygen - PubMed (nih.gov)  Undersea Hyperb Med 2009 Nov-Dec;36(6):391-9.  (2 Airmen suffering from concussions from IED)

Stoller KP Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: two case reports. - Abstract - Europe PMC  Medical gas Research, 05 Jul 2011, 1(1):17   (Great case reports (2) and SPECT scans. Article cites a lot of other good supporting references)

Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995 

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κb signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Vlodavsky, E. Palzur, M. Feinsod, et al. Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, treated by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol., 110 (2) (2005), pp. 120-126

Hadanny A, Abbott S, Suzin G, et al. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387

Tsutsumi I, Tsujimoto Y, Takahashi S, et al. Hyperbaric oxygen therapy for persistent post‐concussion syndrome following mild traumatic brain injury. Cochrane Database Syst Rev. 2017;2017(7):CD012727. Published 2017 Jul 16. doi:10.1002/14651858.CD012727

Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20. doi:10.2147/NDT.S110126

Eyal Bar-Kochba, Mark T. Scimone, Jonathan B. Estrada & Christian Franck. Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury. Scientific Reports Aug 2016; 6:30550 DOI: 10.1038/srep30550

PTSD

Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits - PubMed (nih.gov)

Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20.doi:10.2147/NDT.S110126

Harch PG, Andrews SR, Fogarty EF, et al. Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Med Gas Res. 2017;7(3):156–174. Published 2017 Oct 17. doi:10.4103/2045-9912.215745

He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Treat. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632

MICROBIOME

Naif Alenazi, Hesham Alsaeed, Adel Alsulami, Turki Alanzi.  A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease. International Journal of General Medicine. Oct .2021:14 7099–7105  IJGM_A_336678 7099..7105 (dovepress.com)

Daniel A Rossignol Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis. Med Gas Res. 2012: 2:6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328239/

T Ferraz Frezza, AL Ribeiro de Souza, C Corat Ribeiro Prado, C Nascimento Fernandes de Oliveira, M Palmira Daflon Gremião, S Giorgio, MAH Dolder, P Pinto Joazeiro, S Marques Allegretti. Effectiveness of hyperbaric oxygen for experimental treatment of schistosomiasis mansoni using praziquantel-free and encapsulated into liposomes: assay in adult worms and oviposition. Acta Trop. Oct 2015; 150:182-9 Effectiveness of hyperbaric oxygen for experimental treatment of schistosomiasis mansoni using praziquantel-free and encapsulated into liposomes: assay in adult worms and oviposition - PubMed (nih.gov)

Schmidt TM, Kao JY. A little O2 may go a long way in structuring the GI microbiome. Gastroenterology. 2014;147(5):956–959. doi:10.1053/j.gastro.2014.09.025

Nyabanga CT, Kulkarni G, Shen B. Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. Gastroenterology Report, Volume 5, Issue 4, November 2017, Pages 320–321, https://doi.org/10.1093/gastro/gov038

Albenberg L, Esipova TV, Judge CP, et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, Volume 147, Issue 5,2014,Pages 1055-1063.e8,ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2014.07.020.

Crabbé A, Jensen PO, Bjarnsholt T, et al. Antimicrobial tolerance and metabolic adaptations in microbial biofilms. Trends in Microbiology. Volume 27, Issue 10, 2019, Pages 850-863, ISSN 0966-842X, https://doi.org/10.1016/j.tim.2019.05.003.

STROKE

Rosario ER, Kaplan SE, Khonsari S, et al. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int. 2018;2018:3172679. Published 2018 Oct 9. doi:10.1155/2018/3172679 

Ostrowski RP, Stępień K, Pucko E, Matyja E. The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications. Arch Med Sci. 2017;13(5):1217–1223. doi:10.5114/aoms.2017.65081

Efrati, G. Fishlev, Y. Bechor, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One, 8 (1) (2013

Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166. 

Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One. ;8(1):e53716. doi:10.1371/journal.pone.0053716

Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2

Hadanny A, Golan H, Fishlev G, et al. Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci. ;33(4):471–486. doi:10.3233/RNN-150517

DEMENTIA/ALZHEIMER’S

Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271

Qiang, Li Lan, Xiong Su-qin, Yan Yu-fen, Li Dan, Yan Na-na, Chen Hong-ping, Liu You-ping, Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia, Frontiers in Aging Neuroscience, VOLUME.11.2019 PAGES=86 DOI=10.3389/fnagi.2019.00086 ISSN=1663-4365

AUTISM

Rossignol DA, Bradstreet JJ, Van Dyke K, et al. Hyperbaric oxygen treatment in autism spectrum disorders. Med Gas Res. 2012;2(1):16. Published 2012 Jun 15. doi:10.1186/2045-9912-2-16  Hyperbaric oxygen treatment in autism spectrum disorders - PMC (nih.gov)

Rossignol DA, Rossignol LW, Smith S, et al. Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial [published correction appears in BMC Pediatr. 2012 Dec;42(4):236]. BMC Pediatr. 2009;9:21. Published 2009 Mar 13. https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-9-21

Xiong T, Chen H, Luo R, et al. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2016;10(10):CD010922. Published 2016 Oct 13. doi:10.1002/14651858.CD010922.pub2

Rossignol DA, Rossignol LW. Hyperbaric oxygen therapy may improve symptoms in autistic children. Medical Hypotheses, Volume 67, Issue 2, 2006, Pages 216-228, ISSN 0306-9877, https://doi.org/10.1016/j.mehy.2006.02.009.

Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Frontiers in Physiology. 5  2014  https://pubmed.ncbi.nlm.nih.gov/24795645/

CEREBRAL PALSY

Shai Efrati, Eshel Ben-Jacob, UHM 2014, Vol. 41, No. 2 – HBO2 for Treatment Of Cerebral Palsy: Editorial perspective How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy – An editorial perspective 

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

OTHER NEUROLOGICAL ISSUES

Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med. 2011 Sep-Oct;38(5):345-66. Review. PubMed PMID: 22013761

Hu Q, Manaenko A, Xu T, et al. Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside. Med Gas Res. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720

Taghizadeh Asl M, Nemati R, Chabi N, et al. Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce. BMC Neurol. 2016;16:79. Published 2016 May 26. doi:10.1186/s12883-016-0605-4

Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions - PubMed (nih.gov)

M.Z. Kiralp, Ş Yildiz, D. Vural, et al. Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome. J. Int. Med. Res., 32 (3) (2004), pp. 258-262.

Oroglu B, Turker T, Aktas S, et al. Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves. Undersea Hyperb Med. 2011 Sep-Oct; 38(5): 367–373.

Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hadanny A, Maliar A, Fishlev G, et al. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol. 2016;11:115–125. Published 2016 Dec 29. doi:10.2147/OPTH.S121307

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

More than 60 treatment protocols have been described for sudden sensorineural hearing loss, but the majority of these are not efficacious. The three most promising treatments include corticosteroids, vasodilators, and hyperbaric oxygen therapy. Of these, only hyperbaric oxygen has sufficient randomized controlled trials to have a positive meta-analysis Cochrane review. The Undersea and Hyperbaric Medical Society (UHMS) lists it as an approved condition for the use of HBOT. And yet the FDA still does not approve it. Follow the research and find a HBOT clinic near you especially in the first 3 days as that is when it is the MOST effective.

Temitope G. Joshua, MD, MSc; Aysha Ayub, BSc; Printha Wijesinghe, PhD; Desmond A. Nunez, MD, MBA  Hyperbaric Oxygen Therapy for Patients With Sudden Sensorineural Hearing LossA Systematic Review and Meta-analysis  JAMA Otolaryngol Head Neck Surg. 2022;148(1):5-11. doi:10.1001/jamaoto.2021.2685

Yeji Ahn, Young Joon Seo, and Young Sub Lee   The Effectiveness of Hyperbaric Oxygen Therapy in Severe Idiopathic Sudden Sensorineural Hearing Loss   

J Int Adv Otol. 2021 May; 17(3): 215–220.

AUTOIMMUNE – INFLAMMATION

Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):81-89. Epub 2019 Feb 8.

https://www.ncbi.nlm.nih.gov/m/pubmed/30747094

J. Hui, Z.J. Zhang, X. Zhang, Y. Shen, Y.J. Gao Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord J. Pain, 14 (7) (2013), pp. 747-758

Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, et al. (2015) Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLoS ONE 10(5): e0127012. https://doi.org/10.1371/journal.pone.0127012

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012

Anti-Aging

Ashley M FullerCharles GiardinaLawrence E HightowerGeorge A PerdrizetCassandra A Tierney  Hyperbaric oxygen preconditioning protects skin from UV-A damage - PubMed (nih.gov)  Cell Stress Chaperones​ 2013 Jan;18(1):97-107  doi: 10.1007/s12192-012-0362-2. Epub 2012 Aug 3

Verena L Banszerus, Valentin M Vetter, Bastian Salewsky, Maximilian König, Ilja Demuth Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort - PubMed (nih.gov)  Int J Mol Sci​  2019 Jun 21;20(12):3032  doi: 10.3390/ijms20123032

STEM CELLS

CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage - PubMed (nih.gov) 

(those stem cells are shown to be important in diabetic neuropathic foot ulcer healing in this article Measurements of CD34+/CD45-dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds - PubMed (nih.gov) )

Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology 2006 290:4, H1378-H1386

Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x

Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166. 

Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al. Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol. 2018;9:995. Published 2018 Jul 30. doi:10.3389/fphys.2018.00995

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940

Milovanova TN, Bhopale VM, Sorokina EM, et al. Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol (1985). 2009;106(2):711–728. doi:10.1152/japplphysiol.91054.2008

MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW. Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res. 2019;9(3):139–144. doi:10.4103/2045-9912.266989

MITOCHONDRIA

Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res., 1221 (2008), pp. 126-133

K.R. Dave, R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Pérez-pinzón,

Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice, Neuroscience, Volume 120, Issue 1, 2003, Pages 113-120,

ISSN 0306-4522, https://doi.org/10.1016/S0306-4522(03)00244-6.

Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences, Volume 162, Issue 1, March 2018, Pages 15–23.

Meyer JN, Leung MC, Rooney JP, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. doi:10.1093/toxsci/kft102

GENERAL HEALTH

Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.

FIBROMYALGIA

Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One. 2015;10(5):e0127012. Published 2015 May 26. doi:10.1371/journal.pone.0127012

Hadanny A, Bechor Y, Catalogna M, et al. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse-randomized controlled trial. Front Psychol. 2018;9:2495. Published 2018 Dec 17. doi:10.3389/fpsyg.2018.02495

Efrati S, Hadanny A, Daphna-Tekoah S, et al. Recovery of repressed memories in fibromyalgia patients treated with hyperbaric oxygen – case series presentation and suggested bio-psycho-social mechanism. Front Psychol. 2018;9:848. Published 2018 May 29. doi:10.3389/fpsyg.2018.00848

Yildiz S, Kiralp MZ, Akin A, et al. A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy J. Int. Med. Res., 32 (3) (2004), pp. 263-267

OTHER REFERENCES

https://hyperbaricoxygentreatmentcenter.com/wp-content/uploads/2020/08/Treatment-of-Lyme-disease-with-hyperbaric-oygen-therapy.pdf

https://lymepeople.com/hyperbaric-treatment-for-lyme-disease/

Hyperbaric Oxygenation for Lyme Vasculitis  https://hyperbaricstudies.com/hyperbaric-oxygenation-for-lyme-vasculitis/

https://hyperbaricoxygentreatmentcenter.com/wp-content/uploads/2020/08/Hyperbaric-Oxygen-Therapy-as-an-effective-adjunct-treatment-for-chronic-Lyme-disease.pdf

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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522

Mitochondrial oxidative phosphorylation defect in the heart of subjects with coronary artery disease. Ait-Aissa K, Blaszak SC, Beutner G, et al. Sci Rep. 2019 May 20; 9(1):7623. Epub 2019 May 20.

Jang S, Lewis TS, Powers C, et al. Elucidating mitochondrial electron transport chain supercomplexes in the heart during ischemia-reperfusion. Antioxid Redox Signal. 2017 Jul 1; 27(1):57-69. Epub 2016 Nov 11

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Photobiomodulation Therapy Research

2015 The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases - PMC (nih.gov)

(I know this is not PBMT, but Earthing, or Grounding, provides the same electrons to your body as PBMT so that your energy cycles are fully filled and ready to do work)